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Evolent Level 1 Medical Oncology

Pathways and Low-Value Regimens

Anal Cancer

Regimen Options
Last Updated: 10/01/2026 See Details
Evolent Pathways Febrile Neutropenic Risk Emetogenic Risk References
NON-METASTATIC

Definitive Chemoradiation

mitomycin and 5FU (fluorouracil)

Low Low
 

mitomycin and capecitabine

Low Low
ADVANCED/METASTATIC

Initial Therapy

carboplatin and paclitaxel

Low High
 

carboplatin, paclitaxel and retifanlimab

Low High

Subsequent Therapy

Best Supportive Care or Clinical Trial

Not Applicable Not applicable
NON-METASTATIC

Definitive Chemoradiation

Evolent Pathways

mitomycin and 5FU (fluorouracil)

Febrile Neutropenic Risk
low
Emetogenic Risk
low
Evolent Pathways

mitomycin and capecitabine

Febrile Neutropenic Risk
low
Emetogenic Risk
low
ADVANCED/METASTATIC

Initial Therapy

Evolent Pathways

carboplatin and paclitaxel

Febrile Neutropenic Risk
low
Emetogenic Risk
high
Evolent Pathways

carboplatin, paclitaxel and retifanlimab

Febrile Neutropenic Risk
low
Emetogenic Risk
high

Subsequent Therapy

Evolent Pathways

Best Supportive Care or Clinical Trial

Febrile Neutropenic Risk
na
Emetogenic Risk
na